Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

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I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.

Sam-e is only thing I found that helps my depression.

This is the best SAM-e on the market. It’s effective at lifting mood, without any bad side effects. It doesn’t cause stomach upset, like some other brands.

I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

this product is worth buying it helped my joint pain and added calmness as well