SynName: heregulin, alpha (45kD, ERBB2 p185-activator); neuregulin 1; *Acetylcholine receptor-inducing activity; Breast cancer cell differentiation factor p45; HRG; *Reactivity: Gorilla, Human, Monkey Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity); *Specificity: Human NRG1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.Target Species: Human; *Immunogen Description: Synthetic 17 amino acid peptide from internal region of human NRG1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Gibbon (94%); Mouse, Rat, Hamster, Elephant, Bat, Horse, Pig, Platypus (82%).; *Immunogen: NRG1 / Heregulin / Neuregulin antibody was raised against synthetic 17 amino acid peptide from internal region of human NRG1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Gibbon (94%); Mouse, Rat, Hamster, Elephant, Bat, Horse, Pig, Platypus (82%).; *Accession#: NP_039258.1; NM_013964.3; Q02297; *Description: Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF).; *NCBI Summary: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked t...
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